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你引用了两篇论文 2005年那篇我就不看了。而你引用的2020年这篇论文大体上看上去是一篇水文,但是其中确实引用了诸多其他论文的研究结论,或许可以做为A2的科普文来看。我截取了部分,因为我在回复的时候也只是提了关于喝牛奶肠胃不适的问题,所以我也只看了这一段及结论,为了方便其他人阅读,我直接用谷歌翻译了我复制的这两段文字,乳糖不耐,肠胃不适,蛋白质,你自己品吧,毕竟怎么看待知识,怎么看待科学是自己的事。
5.3 Gastrointestinal disease
There are a number of studies on the impact of A1- or A2-milk on digestive tract health [51, 52]. However, the increasing consumption of dairy products is associated with an increase in the risk of gastrointestinal function [53 -56]. Ho et al., [51] have found that A1-milk led to significantly higher stool consistency values (Bristol Stool Scale) compared with the A2-milk. Furthermore the authors found a significant positive association between abdominal pain and stool consistency on the A1-milk diet (r=0.52), but not the A2-milk diet (r=-0.13). Jianqin et al., [57] reported that the consumption of milk containing both types (A1-milk and A2-milk) was associated with significantly greater post-dairy digestive discomfort symptoms; higher concentrations of inflammation-related biomarkers and BCM-7; longer gastrointestinal transit times and lower levels of short-chain fatty acids. On the other hand, consumption of milk containing only A2-milk did not aggravate post-dairy digestive discomfort symptoms. Other studies in Germany have shown that after the application of A2-milk in 10 people who cannot tolerate A1-milk, have not had gastrointestinal problems [7]. He et al. [52] investigated that milk containing A2-milk attenuated acute gastrointestinal symptoms of milk intolerance, while conventional milk containing A1-milk reduced lactase activity and increased gastrointestinal symptoms. Animal studies have shown that the effect of A1- versus A2-milk on gastrointestinal was directly influenced [56, 58]. Similarly, it has been reported that casein and its derivatives, particularly BCM-7, exert a variety of effects on gastrointestinal function in animals, including reducing the frequency and amplitude of intestinal contractions [53, 59-61]. Interestingly, Barnett et al., [ 56] also shown in rats that A1-milk feeding relative to A2-milk feeding significantly increased the colonic activity of the inflammatory marker myeloperoxidase by 65%, an effect also negated by the opioid blocker naloxone. In general, it has been shown that the consumption of milk containing A1-milk would lead to systemic inflammation and gastrointestinal motility through the release of BCM-7 [51, 57]. In fact, further animal research and clinical trials is needed to compare disease risks of A1-free versus ordinary milk
Conclusion
Whether A2-milk is really healthier than A1-milk or not; farmers, breeders, societies and the media have been dealing with this for several years. The difference between the two milk variants is only a single amino acid deviation of beta casein. In the course of development, the A1-milk mutation has occurred at some point, because the A2-milk is considered the more natural form. A1-milk and the peptide BCM-7 may be linked to heart disease, diabetes, autism, sudden death of infants and inflammation in the digestive system. The results are mixed and further studies are needed
5.3 胃肠道疾病
有许多关于 A1 或 A2 牛奶对消化道健康影响的研究 [51, 52]。然而,乳制品消费量的增加与胃肠功能风险的增加有关 [53 -56]。 Ho 等人 [51] 发现,与 A2 牛奶相比,A1 牛奶导致大便稠度值(布里斯托大便量表)显着升高。此外,作者发现 A1 牛奶饮食的腹痛和大便稠度之间存在显着的正相关关系(r=0.52),而 A2 牛奶饮食则没有(r=-0.13)。 Jianqin 等人 [57] 报告说,食用含有这两种类型的牛奶(A1 牛奶和 A2 牛奶)与更严重的乳制品后消化不适症状相关;更高浓度的炎症相关生物标志物和 BCM-7;更长的胃肠道转运时间和更低水平的短链脂肪酸。另一方面,食用仅含 A2 牛奶的牛奶并不会加重乳制品后的消化不适症状。德国的其他研究表明,在对 10 名不能耐受 A1 奶的人应用 A2 奶后,没有出现胃肠道问题 [7]。他等人。 [52] 研究表明,含有 A2 牛奶的牛奶可以减轻牛奶不耐受的急性胃肠道症状,而含有 A1 牛奶的传统牛奶会降低乳糖酶活性并增加胃肠道症状。动物研究表明,A1 与 A2 牛奶对胃肠道的影响受到直接影响 [56, 58]。同样,据报道,酪蛋白及其衍生物,特别是 BCM-7,对动物的胃肠功能产生多种影响,包括降低肠道收缩的频率和幅度 [53, 59-61]。有趣的是,Barnett 等人,[56] 还在大鼠中显示,相对于 A2 奶喂养,A1 奶喂养显着增加了 65% 的炎症标志物髓过氧化物酶的结肠活性,阿片受体阻滞剂纳洛酮也抵消了这种影响。一般来说,已经表明,摄入含有 A1 的牛奶会通过释放 BCM-7 导致全身炎症和胃肠蠕动 [51, 57]。事实上,需要进一步的动物研究和临床试验来比较无 A1 与普通牛奶的疾病风险
结论
A2牛奶是否真的比A1牛奶更健康;多年来,农民、育种者、社会和媒体一直在处理这个问题。两种牛奶变体之间的差异只是 β 酪蛋白的一个氨基酸偏差。在发育过程中,A1 奶的突变在某个时候发生了,因为 A2 奶被认为是更自然的形式。 A1-牛奶和肽 BCM-7 可能与心脏病、糖尿病、自闭症、婴儿猝死和消化系统炎症有关。结果喜忧参半,需要进一步研究 |
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