有没有人知道美国阿尔尼拉姆公司新药aln vsp？据说可以治愈癌症？

findcaiyzh

据说可以治愈癌症。
有没有人知道这方面信息。什么时候上市，可不可以买到

findcaiyzh

爸爸得了癌，我很想知道这方面的信息。这是一个希望。

aicjt

可以到美国的中文论坛网站上咨询一下

老杏

现在才一期临床试验，没有上市。有没有肯定的效果也不知道。如果你父亲符合这些条件，可以和那个医药公司联系看能不能参与临床实验。

项目负责人的名字是：Akshay Vaishnaw, MD PhD

Criteria


Inclusion Criteria:
•Patients must have histologically or cytologically confirmed advanced solid tumors that have recurred or progressed following standard therapy, or that have not responded to standard therapy, or for which there is no standard therapy, or who are not candidates for standard therapy
•Patient has measurable tumor in the liver
•At least 28 days have elapsed since the patient's prior systemic therapy, radiotherapy, or any major surgery
•Patient has an Eastern Cooperative Oncology Group (ECOG) performance status score of 0-1
•Patient has adequate hematologic, liver, and renal function
•Patient is seronegative for hepatitis B virus (HBV) and hepatitis C virus (HCV)
•Patient has a life expectancy > 12 weeks

Exclusion Criteria:
•Patient is receiving full-dose (therapeutic) anticoagulation therapy and/or aspirin > 325 mg/day or other platelet inhibitory agents
•Patient has clinically significant cardiovascular disease or uncontrolled serious cardiac arrythmia
•Patient has known active brain or leptomeningeal metastases
•Patient has clinically significant cerebrovascular disease
•Patient has a seizure disorder not controlled on medication
•Patient has a known or suspected viral, parasitic or fungal infection
•Patient previously experienced a severe reaction to a liposomal product
•Patient has a known hypersensitivity to lipid products

公司网站是 http://alnylam.com/index.php

[ 本帖最后由 clur 于 2011-5-17 22:19 编辑 ]

老杏

目前只有美国和西班牙有实验基地

Locations



United States, Arizona



TGen Clinical Research Service at Scottsdale Healthcare



Scottsdale, Arizona, United States, 85258



United States, Massachusetts



Dana Farber Cancer Institute



Boston, Massachusetts, United States, 02115



Massachusetts General Hospital



Boston, Massachusetts, United States, 02114



Beth Israel Deaconess Medical Center



Boston, Massachusetts, United States, 02215



United States, Michigan



Karmanos Cancer Center



Detroit, Michigan, United States, 48201



United States, New York



Memorial Sloan-Kettering Cancer Center



New York, New York, United States, 10065



United States, Tennessee



Sarah Cannon Research Institute



Nashville, Tennessee, United States, 37203



Spain



Hospital Virgen del Rocio



Seville, Andalucia, Spain, 41013



Hospital Universitario Vall d'Hebron



Barcelona, Catalonia, Spain, 08035



Hospital Clinico Universitario de Valencia



Valencia, Spain, 46010

findcaiyzh

谢谢！

mingyu

同关注！

sadness

历史性时刻可能越来越近，下周 3/6--7/6 在 Chicago ASCO 2011 年会上将公布 Alnylam's ALN-VSP 最新第一期临床试验结果。同时，Silence 公司也公布同类RNAi 抗癌药 Atu027 第一期临床试验数据。

在这两家RNAi领头公司发布的简短数据看，他们都获得了满意的结果。

其实在世界上还有几家公司（分别在美，英，加）在试验基于RNAi技术的抗癌药，人类有可能在两年内让这类药上市，为癌症病人提供一种只杀癌细胞而对身体其他细胞没有严重毒性的新药。

[ 本帖最后由 sadness 于 2011-5-26 14:56 编辑 ]

findcaiyzh

不知道这种药有没有抗药性

sadness

这类药还处于试验阶段，有没有抗药性估计还不能知道，不过这这类基于RNAi药关键是能否送到目标位置。

路漫漫

家里也有重症病人，期待这种新药问世