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原帖由 bulaohu 于 2011-4-14 18:06 发表 
请你举出这个跟性激素有关的证据。
Androgenetic alopecia (AGA) is the most common type of hair loss in men and women.
证据如下:
More than 50 years ago Hamilton observed that men who were castrated did not develop AGA [17]. Therefore it was concluded that the growth of hair follicles is in some areas androgen-dependent (Table I). At present it is unknown how androgens exert their paradoxical effect on the growth of HF at different body sites, and which genes are involved. However, Hamilton already showed that AGA can be triggerd in castrated men by injecting testosterone. The androgen-dependent nature of AGA is furthermore demonstrated by the lack of frontal recession in androgen-insensitive men who lack functional androgen receptors [18], by the inducibility of AGA in the stump-tailed macaque by T [19], by hair regrowth in women after removal of an androgen-secreting tumor [17], and by the inhibition of ex vivo hair growth by T [20].
17. Hamilton JB. Male hormone stimulation as a prerequisite and an incitement in common baldness. Am J Anat 1942; 71: 451-3.
18. Balducci R, Ghirri P, Brown TR, Bradford S, Boldrini A, Boscherini B, Sciarra F, Toscano V. A clinician looks at androgen resistance. Steroids 1996; 61: 205-11.
19. Takashima I, Montagna W. Studies of common baldness of the stump-tailed macaque (Macaca speciosa). VI. The effect of testosterone on common baldness. Arch Dermatol 1971; 103: 527-34.
20. Obana N, Chang C, Uno H. Inhibition of hair growth by testosterone in the presence of dermal papilla cells from the frontal bald scalp of the postpubertal stumptailed macaque. Endocrinology 1997; 138: 356-61. |
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