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Augmentin Duo 400 Suspension
Dosage and Administration Augmentin Duo 400 should be taken immediately before or with the first mouthful of food, to minimise potential gastrointestinal intolerance and to optimise absorption.
Children aged 2 months up to 12 years. For moderate to severe infections the dose should be 45 mg/kg/day, based on the amoxycillin component, (or clavulanic acid 6.4 mg/kg/day) in two divided doses every 12 hours.
The children's dosage is intended for individuals whose weight will not cause dosage to be calculated greater than that recommended for adults. Children weighing 40 kg and more should be dosed according to the adult recommendations for other Augmentin preparations.
There are no clinical data available for Augmentin Duo 400 in infants with immature renal function. The use of Augmentin Duo 400 in this group cannot be recommended.
Use in hepatic impairment. Data are currently insufficient for a dosage recommendation. Dose with caution and monitor hepatic function at regular intervals.
Use in renal impairment. Augmentin Duo 400 is not recommended for use in children with renal impairment or in haemodialysis. In children with renal impairment, dosage should be adjusted according to degree of impairment using the alternative Augmentin (4:1 ratio) 125 mg/31.25 mg or 250 mg/62.5 mg formulations.
Directions for reconstituting the oral suspension. Prepare the oral suspension at time of dispensing as follows. Tap bottle until all the powder flows freely. Add approximately 1/2 of the total amount of water for reconstitution and shake vigorously to suspend powder. Add remainder of the water and again shake vigorously.
To produce Augmentin Duo 400 Suspension (per 5 mL: amoxycillin 400 mg, clavulanic acid 57 mg), use 107 mL glass bottle, add 55 mL water, for final volume of reconstituted oral suspension of 60 mL.
Shake oral suspension well before using. Reconstituted syrup must be stored under refrigeration (2-8deg. C) and discarded after 7 days.
不好意思,不想翻译了,楼主自己看吧 |
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