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Dosage and Administration Keflex is administered orally.
Adults. The adult dosage ranges from 1 to 4 g daily in divided doses. The usual adult dose is 250 mg every six hours.
For streptococcal pharyngitis or tonsillitis, mild, uncomplicated urinary tract infections and skin and soft tissue infections, a dosage of 500 mg may be administered every 12 hours.
For more severe infections or those caused by less susceptible organisms, larger doses may be needed. If daily doses of Keflex greater than 4 g are required, parenteral cephalosporins, in appropriate doses, should be considered.
Twice daily dosing is not recommended when doses larger than 1 g daily are administered.
Children. The usual recommended daily dosage for children is 25 to 50 mg/kg in divided doses. For streptococcal pharyngitis in patients over 1 year of age, tonsillitis, mild, uncomplicated urinary tract infection and skin and soft tissue infections, the total daily dose may be divided and administered every 12 hours. See Table 2.
KEFLEX02
In severe infections, the dosage may be doubled.
In the therapy of otitis media, clinical studies have shown that a dosage of 75 to 100 mg/kg/day in four divided doses is recommended.
In the treatment of beta-haemolytic streptococcal infections, a therapeutic dosage of Keflex should be administered for at least ten days.
Impaired renal function. See Precautions.
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