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星期天，医生宣布治愈了一个感染HIV的婴儿。这是一个令人吃惊的发现。这个发现可能会导致急剧减少因出生感染而携带HIV病毒的儿童数量。 这个出生在密西西比的婴儿，在出生30小时的时候接受了抗逆转录药物的治疗。通常不会给与婴儿此类治疗。如果进一步研究证实此方法能够在其他婴儿生上有效，几乎会肯定这会改变从母体感染的新生婴儿的治疗方法。联合国统计2011年约有330000婴儿感染HIV。最新数据显示全世界有3百万儿童感染HIV。 此报告确认，这个密西西比的新生儿将成为全球第二例有完整记录的治愈案例。推动了这种在几年前几乎是公认为不可能的研究项目。 Johns Hopkins Medicine 提供的图像上是在Johns Hopkins' Children's Center的Dr. Deborah Persaud 在Baltimore。科学家2013年3月3日宣布一个新生的携带HIV病毒的婴儿，似乎已经被治愈。科学家们描述了这个现年2岁的儿童，已经停止用药1年之久，并且没有感染症状。这个儿童保持无病毒状态。这将成为世界第二例公认的治愈案例。专家称，此发现将提供令人兴奋的如何消除HIV在儿童身上感染的线索。 或许我们能够将病毒消灭在萌芽之中。 世界首例治愈的案例是Timothy Brown，外号“柏林病人”，一个中年白血病男子接受了从天生对HIV有抵抗的捐献者的骨髓移植。 Dr. Deborah Persaud说，对于儿科而言，这个婴儿就是儿科的Timothy Brown，如果能够重复成功这个治疗的话，就能原则证明我们能够治愈HIV感染 另有专家指出，需要证明这个婴儿确实是感染了HIV，然后才被治愈的。否着这只是预防案例并非治愈案例，已有研究能够预防新生婴儿的HIV。 Persaud 医生确信婴儿当时确实被感染HIV。在婴儿出生的第一个月，他们有5个阳性测试结果。现在这个2岁半的婴儿已经完全脱离药物一年，并且没有感染的迹象。 研究计划试验任何早期测试和积极治疗是否对其他婴儿有效。就像骨髓移植治愈了Timothy Brown那样， 密西西比治疗目前不是但将来会成为一个标准的护理方案。 Doctors announced on Sunday that a baby had been cured of an HIV infection for the first time, a startling development that could lead to more aggressive treatment of babies infected at birth and a sharp reduction in the number of children living with the virus that causes AIDS. The baby, born in rural Mississippi, was treated with antiretroviral drugs starting around 30 hours after birth, something that is not usually done. If further study shows this works in other babies, it will almost certainly change the way newborns of infected mothers are treated all over the world. The United Nations estimates that 330,000 babies were newly infected in 2011, the most recent year for which there is data, and that more than 3 million children globally are living with HIV. If the report is confirmed, the child born in Mississippi would be only the second well-documented case of a cure in the world, giving a boost to research aimed at a cure, something that only a few years ago was thought to be virtually impossible. This image provided by Johns Hopkins Medicine shows Dr. Deborah Persaud of Johns Hopkins' Children's Center in Baltimore. A baby, born with the AIDS virus, appears to have been cured scientists announced Sunday, March 3, 2013, describing the case of a child from Mississippi, who's now 2? and has been off medication for about a year with no signs of infection. If the child remains free of HIV, it would mark only the world's second known cure. Specialists say the finding offers exciting clues for how to eliminate HIV infection in children. "Maybe we'll be able to block this reservoir seeding," Persaud said. (AP Photo/Johns Hopkins Medicine) The first person cured was Timothy Brown, known as the "Berlin patient," a middle-aged man with leukemia who received a bone-marrow transplant from a donor genetically resistant to HIV infection. Advertisement "For pediatrics, this is our Timothy Brown," said Dr. Deborah Persaud, associate professor at the Johns Hopkins Children's Center and lead author of the report on the baby. "It's proof of principle that we can cure HIV infection if we can replicate this case." Persaud and other researchers spoke in advance of a presentation of the findings on Monday at the Conference on Retroviruses and Opportunistic Infections in Atlanta. Some outside experts, who have not yet heard all the details, said they needed convincing that the baby had truly been infected. If not, this would be a case of prevention, something already done for babies born to infected mothers. Persaud and some other outside scientists said they were certain the baby had been infected. There were five positive tests in the baby's first month of life. Now 2 1/2 , the child has been off drugs for a year with no sign of functioning virus. Studies are being planned to see if early testing and aggressive treatment can work for other babies. While the bone marrow transplant that cured Timothy Brown is an arduous and life-threatening procedure, the Mississippi treatment is not and could become a new standard of care. Read more: http://www.theage.com.au/world/h ... 20130304-2ffrq.html |
