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Myelodysplastic syndromes (MDS) are a group of diseases which all affect the production of normal blood cells in the bone marrow.In MDS, abnormal bone marrow stem cells produce increased numbers of immature blood cells. These cells do not grow properly and often die prematurely.
Many people, particularly in the early stage of disease remain very well, living a relatively normal life for a long time without any treatment.
If symptoms of anaemia are interfering with your normal daily activities, your doctor may recommend that you have a red blood cell transfusion.
Erythropoeitin (EPO) is an example of a growth factor which is used to stimulate the production of more red blood cells and can in some cases reduce the need for frequent blood transfusions.
In general, chemotherapy is only used in MDS in situations when there is a need to control a rising white cell count or if the MDS is transforming or has transformed into leukaemia.
Stem cell transplantation (also called a bone marrow transplant) using a suitably matched donor, is the only potential cure for MDS.
There are several new approaches being developed for the treatment of MDS. These include new chemotherapy drugs, biological modifiers and immunomodulatory drugs which harness the power of the immune system to help fight disease. |
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