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SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro
Hui Jiang 1,2,* and Ya-Fang Mei 2,*
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Citation: Jiang,H.;Mei,Y.-F. SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. Viruses 2021, 13,2056. https://doi.org/10.3390/ v13102056
Academic Editor: Oliver Schildgen
Received: 20 August 2021 Accepted: 8 October 2021 Published: 13 October 2021
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) has led to the coron- avirus disease 2019 (COVID–19) pandemic, severely affecting public health and the global economy. Adaptive immunity plays a crucial role in fighting against SARS–CoV–2 infection and directly in- fluences the clinical outcomes of patients. Clinical studies have indicated that patients with severe COVID–19 exhibit delayed and weak adaptive immune responses; however, the mechanism by which SARS–CoV–2 impedes adaptive immunity remains unclear. Here, by using an in vitro cell line, we report that the SARS–CoV–2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity. Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines.
Keywords: SARS–CoV–2; spike; DNA damage repair; V(D)J recombination; vaccine
发表于《病毒》（Viruses)期刊论文结论：新冠病毒的刺突蛋白可以进入细胞核且抑制宿主细胞的DNA修复功能，只有全长的(full length)刺突蛋白有抑制作用，目前上市的主要疫苗皆用全长刺突蛋白为抗原…
这是否意味着今后癌症发病率会大幅度提高？因为人体自身每天都有成千上万的细胞突变，有些是癌化突变，如果干扰了修复功能就等于毁了人自身的保护机制。 |
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