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阿尔法D3 is 1-alpha-hydroxycholecalciferol (1αOHD3)
Vitamin D3 is also called cholecalciferol, which can be made in the skin (by sunlight) or ingested (Vitamin D supplement).
Vitamin D3 is then hydroxylated in the liver to 25-hydroxycholecalciferol - 25(OH)D3 or calcidiol
25-hydroxycholecalciferol is further hydroxylated in the kidneys by the enzyme 1α-hydroxylase, into the biologically active hormone 1,25-dihydroxycholecalciferol - 1,25(OH)2D3 or calcitriol
In patient with renal impairement, the kidney coversion is decreased, so Vitamin D3 supplement can not covert to the biologically active 1,25(OH)2D3 or calcitriol.
阿尔法D3 [1α(OH)D3], is not biologically active, it need be coverted to 1,25(OH)2D3 by liver. 阿尔法D3 may not available is Australia.
In Australia, calcitriol, the biologically active form of Vitamin D is used.
Calcitriol is an authority drug, expensive for private prescription ($100 for 100 tablets of 0.25mcg) |
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